Abstract Mitochondrial dysfunctionThis is when mitochondria do not work as well as they should due to another disease or condition. Many conditions can lead to secondary dysfunction. leads to loss of renal function and structure; however, the precise mechanisms by which mitochondrialRelated to the mitochondria. function can regulate renal fibrosisThe thickening and scarring of connective tissue. remain unclear. Proximal tubular cells (PTCs) prefer fatty acid oxidation as their energy source and dysregulation of lipid metabolism has been linked to tubulointerstitial fibrosis (TIF). […]
