The impact of the COVID-19 pandemic on medically fragile populations, who are at higher risk of severe illness and sequelae, has not been well characterized. Viral infection is a major cause of morbidity in children with mitochondrialRelated to the mitochondria. disease (MtD), and the COVID-19 pandemic represents an opportunity to understand host-pathogen interactions. This talk will summarize a number of recent research efforts to understand the impact of COVID-19 on the mitochondrial community.